Hapless museum night watchman Larry Daley must help his living, breathing exhibit friends out of a pickle now that they've been transferred to the archives at the Smithsonian Institution. Larry's (mis)adventures this time include close encounters with Amelia Earhart, Abe Lincoln and Ivan the Terrible. Security guard Larry Daley infiltrates the Smithsonian Institution in order to rescue Jedediah and Octavius, who have been shipped to the museum by mistake.