Rizwan Khan, a Muslim from the Borivali section of Mumbai, has Asperger's syndrome. He marries a Hindu single mother, Mandira, in San Francisco. After 9/11, Rizwan is detained by authorities at LAX who treat him as a terrorist because of his condition and his race. An Indian Muslim man with Asperger's syndrome takes a challenge to speak to the President of the United States seriously and embarks on a cross-country journey.