Italian immigrant Francesca Cabrini arrives in 1889 New York City and is greeted by disease, crime, and impoverished children. Cabrini sets off on a daring mission to convince the hostile mayor to secure housing and healthcare for society's most vulnerable. With broken English and poor health, Cabrini uses her entrepreneurial mind to build an empire of hope unlike anything the world had ever seen. After witnessing disease and poverty in the slums of New York, Italian immigrant Francesca Cabrini embarks on a daring journey to persuade the hostile mayor to provide housing and healthcare for hundreds of orphaned children.