A sexy nightclub owner, Barb Wire moonlights as a mercenary in Steel Harbor, one of the last free zones in the now fascist United States. When scientist Cora Devonshire wanders into Barb's establishment, she gets roped into a top-secret government plot involving biological weapons. Soon Barb is reunited with her old flame Axel Hood, who is now Cora's husband and a guerrilla fighter, resulting in plenty of tense action. During the Second American Civil War in 2017, Barb Wire owns a nightclub called the Hammerhead. Things become complicated when her ex-lover Axel Hood, who is married to the fugitive Corrina Devonshire, re-enters her life.